Elk1 pathway
WebJul 2, 2024 · Additional inhibition of the MAPK pathway reduced reporter activity to 70% and Elk1 knockdown reduced it to 50%, confirming the role of Elk1 as one of the major … The downstream target of Elk1 is the serum response element (SRE) of the c-fos proto-oncogene. To produce c-fos, a protein encoded by the Fos gene, Elk1 needs to be phosphorylated by MAPKs at its C-terminus. MAPKs are the final effectors of signal transduction pathways that begin at the plasma … See more ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by … See more Given its role as a transcription factor, Elk1 is expressed in the nuclei of non-neuronal cells. The protein is present in the cytoplasm as well … See more Aside from the full-length protein, the Elk1 gene can yield two shortened versions of Elk1: ∆Elk1 and sElk1. Alternative splicing produces ∆Elk1. … See more • Overview of all the structural information available in the PDB for UniProt: P19419 (ETS domain-containing protein Elk-1) at the PDBe-KB. See more As depicted in Figure 1, the Elk1 protein is composed of several domains. Localized in the N-terminal region, the A domain is required for the binding of Elk1 to DNA. This region also contains a nuclear localization signal (NLS) and a nuclear export signal (NES), … See more Long-term memory Formation of long-term memory may be dependent on Elk1. MEK inhibitors block Elk1 phosphorylation and, thus, impair acquired conditioned taste aversion. Moreover, avoidance learning, which involves the subject … See more
Elk1 pathway
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WebWet-lab validated real-time PCR primer assays for your biological pathway of interest. Select your gene target of interest using an interactive pathway map, and select your plate. WebMar 16, 2011 · The ERK pathway is also critical for the retrieval (or expression) of a previously established CPP, in the absence of drug administration. Hyperphosphorylation of ERK and Elk-1 in the nucleus accumbens (NAcc) is associated with the expression of methamphetamine- and cocaine-induced CPP (Mizoguchi et al., 2004; Miller and …
WebPhosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy J Mol Cell Cardiol. 2000 Aug;32(8):1447-57. doi: 10.1006/jmcc.2000.1185. ... Elk1 protein, rat Enzyme Inhibitors Flavonoids ... WebSep 16, 2024 · Down-regulated the expression of PTK2 or tyrosine protein kinase Met (c-MET) decreased ETV1-mediated HCC metastasis. Hepatocyte growth factor (HGF) upregulated ETV1 expression through activating c-MET-ERK1/2-ELK1 pathway. Notably, in two independent cohorts, patients with positive coexpression of ETV1/PTK2 or ETV1/c …
WebLncRNA 00662 upregulated the expression of ELK1 through sponging miR-30b-3p to promote the malignant behavior of OS cells 55. LncRNA MRPL23-AS1 activated the Wnt/β-Catenin signaling pathway by inhibiting miR-30b and upregulating myosin heavy chain 9 (MYH9), thereby facilitating tumor progression and carcinogenesis in OS 56. WebSep 9, 2024 · Reciprocally, CCL2 activated the CCR2-ERK-ELK1-EGR1 pathway, thus forming a positive feed-forward loop. Moreover, CCL2 in culture medium of SGC7901R cells promoted angiogenesis of Human Umbilical Vein Endothelial Cells (HUVECs). EGR1 expression was positively correlated with CCL2 and ZEB2 in clinical GC tissues, and the …
WebThe MAPK/ERK signaling pathway is a major participant in the regulation of cell growth and differentiation. It can be activated by various extracellular stimuli including mitogens, growth factors, and cytokines. ... including …
WebJul 26, 2024 · ELK1 is activated by the ERK1/2, p38, and SAPK/JNK pathways, with each pathway targeting a different ELK1 domain (Yang et al., 1998). The p38 and SAPK/JNK pathways activate ETV4 (Selvaraj et al., 2015). We report that Ang-1-induced upregulation of ETS1 in HUVECs is dependent on the p38, SAPK/JNK, and PI-3 kinase/AKT pathways. egat project south bangkokWebFeb 15, 2002 · The involvement of the Ras-Raf-MEK-Erk pathway in Elk1 activation in our assay was confirmed with the use of the well-characterized MEK1 inhibitor PD98059 and the dominant-negative RasN17 mutant. Furthermore, the effect of Gab2 overexpression on Erk2 activation was directly demonstrated in the 3 stable K562 cell lines expressing Gab2WT. egat is ice type weak againstWebFor example, ELK1 is modified by SUMO, and this modification is reversed by ERK–MAP kinase pathway activation. Mechanistically, it has been shown that sumoylation of ELK1 … egat organization chartWebApr 4, 2024 · Furthermore, we found that hsa_circ_0008500 attenuated HG-mediated ADSCs apoptosis. In addition, Hsa_circ_0008500 could directly interact with hsa-miR-1273h-5p, acting as a miRNA sponge, which subsequently suppressed Ets-like protein-1(ELK1) expression, the downstream target of hsa-miR-1273h-5p. egat officeWebMar 1, 2024 · Background: The ERK MAPK pathway plays a pivotal role in regulating numerous cellular processes during normal development and in the adult but is often deregulated in disease scenarios. One of its key nuclear targets is the transcription factor ELK1, which has been shown to play an important role in controlling gene expression in … egats the logo with a baskrtball inside a uWebOct 12, 2024 · Interestingly, Ang II can promote the binding of ELK1 to the promoter of RBM20 and enhance the transcriptional activity of RBM20. Previous studies indicated that hormones can induce phosphorylation of ELK1 through the MAPK signaling pathway and thereby control gene transcription and expression [43,44]. egat non firmWebThe transcription factor Elk-1 is downstream of ERK, and its activity, regulated by ERK-dependent phosphorylation, leads to transcriptional activation of target genes (Davis, … eg at the beginning of a sentence